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Attenuated adenosine to inosine editing of microRNA 376a

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Related Commentary, page 3842 Research article Attenuated .

Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells Yukti Choudhury,1 Felix Chang Tay,2 Dang Hoang Lam,1,2 Edwin Sandanaraj,3 Carol Tang,4 Beng-Ti Ang,3,4 and Shu Wang1,2 1Institute of Bioengineering and Nanotechnology, Singapore.

Resear

... E. Sandanaraj, C. Tang, B. T. Ang and S. Wang , " Attenuated Adenosine-to-Inosine Editing of MicroRNA-376a* Promotes Invasiveness of Glioblastoma Cells ," Journal of Clinical Investigation , 122[11] (2012) 4059-4076 ...

Attenuated adenosine-to-inosine editing of microRNA-376a .

In the human brain, microRNAs (miRNAs) from the microRNA-376 (miR-376) cluster undergo programmed "seed" sequence modifications by adenosine-to-inosine (A-to-I) editing. Emerging evidence suggests a link between impaired A-to-I editing and cancer, particularly in high-grade gliomas.

Adenosine-to-inosine RNA editing and human disease .

A-to-I RNA editing is a post-transcriptional modification that converts adenosines to inosines in both coding and noncoding RNA transcripts. It is catalyzed by ADAR (adenosine deaminase acting on RNA) enzymes, which exist throughout the body but are most prevalent in the central nervous system. Inosines exhibit properties that are most similar to those of guanosines.

ADAR Enzyme and miRNA Story: A Nucleotide that Can Make the Difference - Open Access Libra

Adenosine deaminase acting on RNA (ADAR) enzymes convert adenosine (A) to inosine (I) in double-stranded (ds) RNAs. Since Inosine is read as Guanosine, the biological consequence of ADAR enzyme activity is an A/G conversion within RNA molecules. A-to-I ...

Attenuated adenosine-to-inosine editing of microRNA-376a .

Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells. Yukti Choudhury, 1 Felix Chang Tay, 2 Dang Hoang Lam, 1, 2 Edwin Sandanaraj, 3 Carol Tang, 4 Beng-Ti Ang, 3, 4 and Shu Wang 1, 2 ... Roles of attenuated miR-376a*editing in regulation of glioma cell invasion and migration.

Micro-editing mistake translates into a devastating brain .

See the article "Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells" on page 4059. Abstract RNA modifications are increasingly being recognized as critical players in cancer.

JCI - Attenuated adenosine-to-inosine editing of microRNA .

In the human brain, microRNAs (miRNAs) from the microRNA-376 (miR-376) cluster undergo programmed “seed” sequence modifications by adenosine-to-inosine (A-to-I) editing. Emerging evidence suggests a link between impaired A-to-I editing and cancer, particularly in high-grade gliomas.

About

Information include but are not limited to qRT-PCR, methylation, microRNA, gene expression, genome copy number etc. ... Wang S (2012) Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells. J Clin Invest ...

ADAR1 and MicroRNA; A Hidden Crosstalk in ... - Semantic Scholar - MAFIADOC.C

Apr 11, 2017 - The result of RNA editing is usually adenosine to inosine (A-to-I) or cytidine to uridine (C-to-U) transi... Home Add Document Sign In Create An Account ADAR1 and MicroRNA; A Hidden Crosstalk in ...

Neuro-Oncology Research Laborato

Lower levels of adenosine-to-inosine editing of mRNAs have been observed in some cancers, particularly in high-grade gliomas. Our work combining basic science, ...

Differential roles of Rap1 and Rap2 small GTPases in neurite retraction and synapse elimination in hippocampal spiny neurons - Fu - 2006 - Journal .

Differential roles of Rap1 and Rap2 small GTPases in neurite retraction and synapse elimination in hippocampal spiny neurons Authors ... Beng-Ti Ang, Shu Wang, Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness ofJournal of, , ...

Frontiers | Disruption of the expression and function of microRNAs in lung cancer as a result of epigenetic changes | Geneti

... Y., Tay, F. C., Lam, D. H., Sandanaraj, E., Tang, C., Ang, B. T., et al. (2012). Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells ...

shu wang - Google Scholar Citatio

This "Cited by" count includes citations to the following articles in Scholar. The ones marked * may be different from the article in the profile.

Serum microRNA-376 family as diagnostic and prognostic markers in human gliomas - IOS Pre

Serum microRNA-376 family as diagnostic and prognostic markers in human gliomas Article type: Research Article Authors: Huang, Qing ...

ncRNA Editing: Functional Characterization and Computational Resources | SpringerLi

Kawahara Y, Zinshteyn B, Sethupathy P et al (2007) Redirection of silencing targets by adenosine-to-inosine editing of miRNAs. ... Choudhury Y, Tay FC, Lam DH et al (2012) Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of ...

The Isoforms of MiRNA—IsomiR - bjmu.edu.

The Isoforms of MiRNA—IsomiR XIE Zhao-Hui1),2),3)*,LI Xue-Gui1),2),3), XU Ti-Sen1),2),3) 1) College of Life Sciences, Dezhou University, Dezhou253023, Shandong, China; 2) Key University Laboratory of Biotechnology and Bio resource Utilization of Shandong ...

MicroRNAs in cancer: biomarkers, functions and therapy .

In just a few short years microRNAs have become firmly established as key molecular components of the cell in both normal and pathologic states [1]. Cancer in particular has been a major focus of microRNA research over the past decade, and many studies have demonstrated the importance of microRNAs in cancer biology through controlling expression of their target mRNAs to facilitate tumor growth ...

Processes | Free Full-Text | ADAR Mediated RNA Editing Modulates MicroRNA Targeting in Human Breast Cancer | HT

Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells. J. Clin ... de Jde, D.; Mazo, J. Hourca Del Reprogramming of microRNAs by adenosine-to-inosine editing and the selective elimination of edited 2013, ...

Altered expression and editing of miRNA-100 regulates iTreg differentiation | Nucleic Acids Research | Oxford Academ

Kawahara et al. have shown that the brain specific editing of miR-376a-5p in its seed region alters its targets. ... Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells J. Clin. Invest. 2012 122 4059 4076 Crossref ...

RNA Editing Mistake Promotes Brain Tumour Developme

RNA Editing Mistake Promotes Brain Tumour Development Assoc Prof Wang Shu Department of Biological Sciences ... S., Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells. Journal of Clinical 122, 4059 ...